Hypoimmunoglobulin G, hyperimmunoglobulin M, intestinal nodular hyperplasia, and thrombocytopenia. An unusual association.

Abnormalities of serum immunoglobulin levels are frequently associated with such haematological disorders as primary aregenerative anaemia, haemolytic anaemia, neutropenia, thrombocytopenia, and leukaemia (Good et al., 1962). Recently, Hermans et al. (1966) reported a group of patients with nodular intestinal lymphoid hyperplasia and hypoy-globulinaemia. We have now seen thrombocytopenia, immunoglobulin abnormalities (hypoIgG with hyper-IgM), and intestinal lymphoid hyperplasia in a 2-year-old girl. This combination of features emphasizes the common origin of functional cells of the immunoglobulin production and haematopoietic systems, and provides interesting speculation on the relation between intestinal lymphoid tissue and immunity.